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Chinese Herbal Preparations Exert Strong Effects on Asthma and Atopy 2
In another study under the direction of Dr. Li, Julie Wang, MD, from the department of Allergy and Immunology and Pediatric Allergy and Immunology at Mount Sinai, presented results of a phase one safety study of Food Allergy Herbal Formula (FAHF)-2, which consists of 9 herbs. Laboratory studies showed that FAHF-2 ”completely protected a murine model against peanut-induced anaphylaxis for as long as 6 months.” Dr. Wang said.
The investigators studied the safety of FAHF-2 in 12 patients with a history of peanut, tree nut, fish, or shellfish allergy in a dose-escalation study. They were randomized to 2.2g (4 tablets), 3.3g (6 tablets), or 6.6g(12 tablets) 3 times daily for 7 days. Subjects continued allergen avoidance for the duration of the study. “All of the patients successfully completed treatment.” Dr. Wang reported. “There were no significant differences in vital signs, laboratory data, electro cardiographic findings, or pulmonary-function tests before or after treatment.” “Only 2 patients reported mild gastrointestinal symptoms, 1 on FAHF-2 and 1 on placebo, which resolved without any need for treatment,” she said. “We don’t know the clinical effect at this time. This was a safety study, and FAHF-2 is safe. However, we saw a significant drop in cytokines, especially interleukin-5, with active treatment (P<0.0008), ” Dr. Wang said. “We are ready to continue efficacy studies now.”
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